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In animals, unlike the deletion of Slc7a11 , the deletion of the GGT family member Ggt1 results in increased GSH levels in urine, reduced cysteine levels in tissues and perinatal lethality 24

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Tosatto SCE, Bosello V, Fogolari F et al (2008) The catalytic site of glutathione peroxidases

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Additionally, carbon units for the folate cycle can also be derived from formate, which can donate one carbon directly to tetrahydrofolate in a reversible reaction catalyzed by the tri-enzyme Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase, and Formyltetrahydrofolate Synthetase 1 (MTHFD1)

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